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  • The difference between efficacy and effectiveness
    • Expected results in a specific population
    • Expected results in an open population
    • Cost to be absorbed for non-effective treatments
    • Cost to be absorbed for adverse effects

 

  • Changes in treatment costs over a period of time
    • Yearly adjustments due to expected inflation

 

  • Decrease in effectiveness over time
    • Scenarios with different rates in the loss of effectiveness
    • Calculation of optimal procedure times using time-dependent acceptability curves
    • Calculation of cost per patient over a period of time (using the cost function and changes in effectiveness)
 

 

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